ZERO - Ricerche sull'inalazione dell'acido ascorbico

Pubblicato il : 02/07/2020 - Categorie : ZERO

Nell’ottobre del 1993, un gruppo di ricercatori condusse test clinici utilizzando l’acido ascorbico nebulizzato per aiutare a smettere di fumare.

L’acido L-ascorbico, e’ uno dei componenti del complesso vitaminico C.

In uno studio recente sono stati condotti due test clinici usando un aerosol di acido ascorbico come sostituto sensoriale.

Lo studio 1 ha esaminato l'efficacia generale dell acido ascorbico utilizzando un dispositivo sostitutivo.

La sigaretta sostitutiva consiste in un tubo delle stesse dimensioni che sprigiona un aerosol di acido ascorbico (circa 1mg/puff, fino ad un massimo di 300mg/giorno). Lo studio e’stato condotto per 3 settimane, dimostrando che i soggetti dopo aver smesso di utilizzare il dispositivo non mostravano alcuna astinenza. 

Lo studio 2 è stato condotto concentrandosi specificatamente sul ruolo delle sensazioni tracheobronchiali per alleviare la voglia di sigaretta.

Sono stati comparati due diversi modi di somministrare acido ascorbico.

Un dispositivo emette particelle fini di acido ascorbico con l'obiettivo di raggiungere la trachea, mentre l'aLtro dispositivo emette particelle più grossolane senza l'obiettivo di raggiungere la trachea o le vie aeree inferiori.

Un iniziale aumento della riduzione al fumo è stata riscontrato nei soggetti utilizzatori del dispositivo emanante particelle fini rispetto a quello emanante particelle più grossolane.

Alla fine del trattamento (5 settimane) entrambi i gruppi hanno mostrato simili diminuzioni alla riduzione nella necessità di fumare.

Negli utilizzatori del dispositivo emanante particelle fini inoltre e’ stato riscontrato una riduzione di voglia di sigarette e umore negativo, ma anche una riduzione della fame.

Questi risultati suggeriscono che l acido ascorbico assunto con una sigaretta sostitutiva, può essere efficace a ridurre l’astinenza dal fumo con conseguente riduzione del fumo che è considerato la più grande causa di morte prevenibile al mondo.

UNO STUDIO SULL'INALAZIONE DELL'ACIDO ASCORBICO

1993 Oct;33(3):211-23. doi: 10.1016/0376-8716(93)90108-3.

Clinical Trials Using Ascorbic Acid Aerosol to Aid Smoking Cessation

E D Levin  1 , F Behm, E Carnahan, R LeClair, R Shipley, J E Rose

Affiliations expand

PMID: 8261886 DOI: 10.1016/0376-8716(93)90108-3

Abstract

Sensory aspects of cigarette smoke are important for providing smoking satisfaction. In previous studies, we have found that substitution of the sensory cues of smoking with a citric acid aerosol significantly reduces craving for cigarettes and enhances smoking reduction and cessation with people trying to quit smoking cigarettes. In the current study, we conducted two clinical smoking cessation trials using an ascorbic acid aerosol as a sensory substitute. The cigarette substitute consisted of a cigarette-sized tube which delivered a fine aerosol of ascorbic acid (approx. 1 mg/puff, up to a maximum of 300 mg/day). Study 1 examined the overall effectiveness of the ascorbic acid smoking substitute device. One group of subjects which used the device and received clinical counseling was compared with another group which received only clinical counseling. The group using the device showed significantly greater abstinence rates at 3 weeks post-cessation. After the subjects stopped using the device, no difference in abstinence was detected. Study 2 was conducted to focus specifically on the role of tracheobronchial sensations in relieving craving for cigarettes. Two closely matched ascorbic acid delivery systems were compared. One device delivered fine particles of ascorbic acid that were targeted to reach the trachea, while the other delivered coarser particles of ascorbic acid that were not expected to reach the trachea or lower airways. An initial enhancement in smoking reduction was found for subjects using the fine particle device relative to those using the coarse particle device. However, by the end of treatment (5 weeks) both groups showed similar degrees of smoking reduction. For those who were abstinent from smoking at the end of treatment, craving for cigarettes and negative mood were both significantly lower for those using the fine particle device. Also, hunger for food was significantly lower in the fine particle device group. These results suggest that ascorbic acid delivered from a cigarette substitute may be effective in reducing smoking and promoting smoking abstinence.

Vitamins and antioxidants

Smoking is basically associated with the decrease plasma concentration of vitamins (A, E, C) and antioxidants; therefore plasma resistance towards oxidative changes decreases. Studies confirmed that use of natural agents along with pharmacological therapy is very effective in smoking cessation.11 According to different studies smokers usually have a low level of ascorbic acid than non-smokers and more than one year without smoking is required to attain plasma concentrations similar to those of people who have never smoked.12-14 Medicinal herbs like Eugenia aromaticum and Astragalus membranaceus have high antioxidant activity and studies proved that they have an important role in reducing withdrawal symptoms.15 It is also found from studies that daily supplements of Oat extract is beneficial in smoking cessation by reducing the consumption of cigarettes from 20 to fewer than 9.

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